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She continued her education at the National Theatre Conservatory, where she obtained her Master of Fine Arts degree in 2002.
After making various guest appearances on Law & Order: Special Victims Unit, Dragnet (2003), and NUMB3RS, Callies gained a starring role on Fox's Prison Break as Sara Tancredi.
The 38-year-old American star, who played the prison medic Sara Tancredi in the drama, is currently in negotiations to reprise her role in the upcoming reboot.
She admitted in a recent interview that she would love to come back, but it is all dependent on schedules as she is working on another show at the moment.
As Prison Break fans will remember, Michael Scofield (Wentworth Miller) and Sara had a relationship in the show.
She is best known for her portrayals of Sara Tancredi in Fox's Prison Break, Lori Grimes in AMC's The Walking Dead and Katie Bowman in USA Network's Colony.After graduating from high school, she entered Dartmouth College in Hanover, New Hampshire.In conjunction with her studies, Callies remained involved in theatre.She is the daughter of Valerie Wayne(mother) and David E.Callies(father), respective English and law professors at the University of Hawaii, Manoa.
It was recently announced that the part of Sara’s husband in the Prison Break revival has been cast.